SB02024

• Target:

  STAT|||Others|||PI3K|||CXCR

• Related Pathways:

  Immunology/Inflammation|||JAK/STAT signaling|||Autophagy|||Others|||PI3K/Akt/mTOR signaling|||GPCR/G Protein|||Stem Cells

• Bioactivity:

  SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity to Sunitinib and Erlotinib and that Vps34 is a promising therapeutic target for combination strategies in breast cancer.

• Smiles:

  [C@](F)(F)(F)[C@@H]1N(CCCC1)C2=CC(=CC(=O)N2)N3[C@H](C)COCC3

• Molecular Formula:

  C16H22F3N3O2

• Molecular Weight:

  345.36

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2126737-28-6