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SB02024

CAT: 0931-T69888-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T69888-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2126737-28-6
Target
STAT, Others, PI3K, CXCR
Related Pathways
Immunology/Inflammation, JAK/STAT signaling, Autophagy, Others, PI3K/Akt/mTOR signaling, GPCR/G Protein, Stem Cells
Bioactivity
SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity to Sunitinib and Erlotinib and that Vps34 is a promising therapeutic target for combination strategies in breast cancer.
Smiles
[C@](F)(F)(F)[C@@H]1N(CCCC1)C2=CC(=CC(=O)N2)N3[C@H](C)COCC3
Molecular Formula
C16H22F3N3O2
Molecular Weight
345.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5812432SB02024
HY-122891A-01(2S) -SB02024

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