SB02024

CAT: 0804-HY-122891-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-122891-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity[1][2][3].

CAS Number

2126737-28-6

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CXCR; PI3K; STAT

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sb02024.html

Purity

99.70

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(N2[C@H](C)COCC2)C=C(N3[C@@H](C(F)(F)F)CCCC3)N1

Molecular Formula

C16H22F3N3O2

Molecular Weight

345.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Noman MZ, et al. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy. Sci Adv. 2020 Apr 29;6 (18) :eaax7881.|[2]Yu Y, et al. Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy. Mol Oncol. 2024 Mar 20.|[3]Bassam Claude JANJI, et al. Biomarker. Patent WO2020008046 A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT1; Vps34

Alternative Products

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T69888-01	SB02024
T207288-01	(2S) -SB02024

SB02024

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