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SB02024

CAT: 0013-GTR19210121-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19210121-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB02024 is a VPS34 inhibitor that blocks autophagy, activates cGAS-STING signaling, and sensitizes tumors to STING agonists. It demonstrates efficacy in reducing breast cancer xenograft growth and, in vitro, significantly enhances the cytotoxicity of Sunitinib and Erlotinib in monolayer and spheroid models of MDA-MB-231 and MCF-7 cells.
CAS Number
2126737-28-6
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Smiles
[C@] (F) (F) (F) [C@@H]1N (CCCC1) C2=CC (=CC (=O) N2) N3[C@H] (C) COCC3
Molecular Formula
C16H22F3N3O2
Molecular Weight
345.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-[(3R)-3-methylmorpholin-4-yl]-6-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-1,2-dihydropyridin-2-one
CAS Number2126737-28-6
PubChem CID141711558
IUPAC Name4-[(3R)-3-methylmorpholin-4-yl]-6-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-1H-pyridin-2-one
Molecular FormulaC16H22F3N3O2
Molecular Weight345.36
XLogP2.5
Topological Polar Surface Area44.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count24
Formal Charge0
Complexity559
SMILES
C[C@@H]1COCCN1C2=CC(=O)NC(=C2)N3CCCC[C@@H]3C(F)(F)F
InChI
InChI=1S/C16H22F3N3O2/c1-11-10-24-7-6-21(11)12-8-14(20-15(23)9-12)22-5-3-2-4-13(22)16(17,18)19/h8-9,11,13H,2-7,10H2,1H3,(H,20,23)/t11-,13-/m1/s1
InChIKey
IARAUFAUVKBTEM-DGCLKSJQSA-N
Chemical Structure
2D Structure
2D structure of 4-[(3R)-3-methylmorpholin-4-yl]-6-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-1,2-dihydropyridin-2-one
CAS: 2126737-28-6
CID: 141711558
Formula: C16H22F3N3O2
MW: 345.36
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight345.36
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass345.16641144
Monoisotopic Mass345.16641144
Topological Polar Surface Area44.8 Ų
Heavy Atom Count24
Formal Charge0
Complexity559
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T69888-01SB02024
HY-122891A-01(2S) -SB02024

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