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MIF degrader MD13

CAT: 0931-T69525Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T69525Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2758431-97-7
Target
PROTACs, Others, MIF
Related Pathways
PROTAC, Immunology/Inflammation, Others
Bioactivity
MIF degrader MD13 is involved in protein-protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tautomerase active siteMIF degrader MD13. MD13 also exhibits antiproliferative effect in a 3D tumor spheroid model. In conclusion, we describe the first MIF-directed PROTAC (MD13) as a research tool, which also demonstrates the potential of PROTACs in cancer therapy.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCCCC(NC4=CC=C(C=C4)N5CC=6C(OC5=O)=CC(O)=CC6)=O
Molecular Formula
C35H35N5O8
Molecular Weight
653.68
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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