PHA-680626

• Target:

  Bcr-Abl|||Aurora Kinase|||Apoptosis|||c-Myc|||Histone Methyltransferase|||Others

• Related Pathways:

  Cell Cycle/Checkpoint|||Others|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis

• Bioactivity:

  PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 ?M), Plk2 (IC50 = 0.07 ?M) and Plk3 (IC50 = 1.61 ?M) .

• Smiles:

  N(C(=O)C1=CC=C(C=C1)N2CCN(C)CC2)C=3C4=C(CN(C(CC5=CC=CS5)=O)C4)NN3

• Molecular Formula:

  C23H26N6O2S

• Molecular Weight:

  450.56

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  398493-74-8