PHA-680626

CAT: 0931-T69296-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T69296-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
398493-74-8
Target
Bcr-Abl|||Aurora Kinase|||Apoptosis|||c-Myc|||Histone Methyltransferase|||Others
Related Pathways
Cell Cycle/Checkpoint|||Others|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Apoptosis
Bioactivity
PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 ?M), Plk2 (IC50 = 0.07 ?M) and Plk3 (IC50 = 1.61 ?M) .
Smiles
N(C(=O)C1=CC=C(C=C1)N2CCN(C)CC2)C=3C4=C(CN(C(CC5=CC=CS5)=O)C4)NN3
Molecular Formula
C23H26N6O2S
Molecular Weight
450.56
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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