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4SC-207

CAT: 0931-T68480-03Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T68480-03Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
871015-11-1
Target
Others
Related Pathways
Others
Bioactivity
4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.
Smiles
C(#N)C=1C2=C(SC1NC(C=CC=3C=CC=NC3)=O)CN(C(OCC)=O)CC2
Molecular Formula
C19H18N4O3S
Molecular Weight
382.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

CID 72252415
CAS Number871015-11-1
PubChem CID72252415
IUPAC Nameethyl 3-cyano-2-(3-pyridin-3-ylprop-2-enoylamino)-5,7-dihydro-4H-thieno[2,3-c]pyridine-6-carboxylate
Molecular FormulaC19H18N4O3S
Molecular Weight382.4
XLogP2.5
Topological Polar Surface Area124
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity632
SMILES
CCOC(=O)N1CCC2=C(C1)SC(=C2C#N)NC(=O)C=CC3=CN=CC=C3
InChI
InChI=1S/C19H18N4O3S/c1-2-26-19(25)23-9-7-14-15(10-20)18(27-16(14)12-23)22-17(24)6-5-13-4-3-8-21-11-13/h3-6,8,11H,2,7,9,12H2,1H3,(H,22,24)
InChIKey
KNQCFGQPDILWLT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 72252415
CAS: 871015-11-1
CID: 72252415
Formula: C19H18N4O3S
MW: 382.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight382.4
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass382.10996162
Monoisotopic Mass382.10996162
Topological Polar Surface Area124 Ų
Heavy Atom Count27
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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HY-1112514SC-207
M28711-014SC-203
B4106-104SC-202
TRC-S199210-1G4SC 203

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