4SC-207

CAT: 0931-MF-0058983-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0058983-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
871015-11-1
Target
Others
Related Pathways
Others
Bioactivity
4SC-207 is a novel microtubule inhibitor , which shows strong anti-proliferative activity in a large panel of tumor cell lines with an average GI50 of 11 nM. In particular, 4SC-207 is active in multi-drug resistant cell lines, such as HCT-15 and ACHN, suggesting that it is a poor substrate for drug efflux pumps. 4SC-207 inhibits microtubule growth in vitro and in vivo and promotes, in a dose dependent manner, a mitotic delay/arrest, followed by apoptosis or aberrant divisions due to chromosome alignment defects and formation of multi-polar spindles. Furthermore, preliminary data from preclinical studies suggest low propensity towards bone marrow toxicities at concentrations that inhibit tumor growth in paclitaxel-resistant xenograft models. 4SC-207 may be a potential anti-cancer agent.
Smiles
C(#N)C=1C2=C(SC1NC(C=CC=3C=CC=NC3)=O)CN(C(OCC)=O)CC2
Molecular Formula
C19H18N4O3S
Molecular Weight
382.44
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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