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Tyrphostin AG 538

CAT: 0931-T67707-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T67707-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
133550-18-2
Target
IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors
Purity
>99.99%
Bioactivity
Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC50 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
Smiles
C(/C(=C/C1=CC(O)=C(O)C=C1)/C#N)(=O)C2=CC(O)=C(O)C=C2
Molecular Formula
C16H11NO5
Molecular Weight
297.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

AG-538

3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile is a member of chalcones.

CAS Number133550-18-2
PubChem CID5328760
IUPAC Name(E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
Molecular FormulaC16H11NO5
Molecular Weight297.26
XLogP2.2
Topological Polar Surface Area122
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count22
Formal Charge0
Complexity494
SMILES
C1=CC(=C(C=C1/C=C(\C#N)/C(=O)C2=CC(=C(C=C2)O)O)O)O
InChI
InChI=1S/C16H11NO5/c17-8-11(5-9-1-3-12(18)14(20)6-9)16(22)10-2-4-13(19)15(21)7-10/h1-7,18-21H/b11-5+
InChIKey
CANOJKGQDCJDOX-VZUCSPMQSA-N
Chemical Structure
2D Structure
2D structure of AG-538
CAS: 133550-18-2
CID: 5328760
Formula: C16H11NO5
MW: 297.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight297.26
XLogP32.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass297.06372245
Monoisotopic Mass297.06372245
Topological Polar Surface Area122 Ų
Heavy Atom Count22
Formal Charge0
Complexity494
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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