NLRP3 modulator 8

• Target :

  NOD

• Related Pathways :

  Immunology/Inflammation|||NF-?B

• Bioactivity :

  NLRP3 modulator 8 (Compound 14) is an NLRP3 regulator that can significantly degrade the NEK7 protein (DC50 = 9 nM) . In macrophages, NLRP3 modulator 8 can inhibit the activity of caspase-1 in a dose-dependent manner and reduce the release of IL-1? triggered by the activation of the NLRP3 inflammasome. NLRP3 modulator 8 is applicable for the research of various diseases, including autoinflammatory and autoimmune diseases, neurodegenerative diseases, as well as cardiovascular and metabolic-related diseases, etc.

• Smiles :

  FC1=CN=C(C(C)(C)C(NCC2=CC(Cl)=C(C3C(NC(CC3)=O)=O)C(Cl)=C2)=O)N=C1

• Molecular Formula :

  C20H19Cl2FN4O3

• Molecular Weight :

  453.3

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3069891-88-6