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NLRP3 modulator 8

CAT: 0931-T212625-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212625-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3069891-88-6
Target
NOD
Related Pathways
Immunology/Inflammation, NF-κB
Bioactivity
NLRP3 modulator 8 (Compound 14) is an NLRP3 regulator that can significantly degrade the NEK7 protein (DC50 = 9 nM) . In macrophages, NLRP3 modulator 8 can inhibit the activity of caspase-1 in a dose-dependent manner and reduce the release of IL-1β triggered by the activation of the NLRP3 inflammasome. NLRP3 modulator 8 is applicable for the research of various diseases, including autoinflammatory and autoimmune diseases, neurodegenerative diseases, as well as cardiovascular and metabolic-related diseases, etc.
Smiles
FC1=CN=C(C(C)(C)C(NCC2=CC(Cl)=C(C3C(NC(CC3)=O)=O)C(Cl)=C2)=O)N=C1
Molecular Formula
C20H19Cl2FN4O3
Molecular Weight
453.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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