NLRP3-IN-32

CAT: 0931-T209380-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T209380-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

NF-κB, NOD-like Receptor (NLR), Reactive Oxygen Species, IκB/IKK

Related Pathways

NF-κB, Metabolism, Immunology/Inflammation

Bioactivity

NLRP3-IN-32 (compound 7a) is a derivative of 3,4-dihydronaphthalene-1 (2H) -one and acts as an inhibitor of the NLRP3 inflammasome. It obstructs the assembly and activation of the NLRP3 inflammasome by downregulating the expression of NLRP3 and the apoptosis-associated speck-like protein containing a CARD (ASC), thereby reducing the production of reactive oxygen species (ROS) and other inflammatory mediators. Additionally, NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65, as well as the nuclear translocation of p65, thus suppressing NF-κB signaling.

Molecular Formula

C21H22BrN3O

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-161329	NLRP3-IN-32
QY-E06005	Human NLRP3 Inflammasome (NLRP3)
MBS8534011-01	NLRP3
BA6124-10	NLRP3-IN-17
BA6050-10	NLRP3-IN-25

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