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NLRP3-IN-8

CAT: 0931-T62221-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T62221-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2768650-56-0
Target
Others, NOD-like Receptor (NLR)
Related Pathways
Others, Immunology/Inflammation
Bioactivity
NLRP3-IN-8 (compound 27), an orally active NLRP3 inflammasome inhibitor, directly binds to its target with an IC50 of 1.23 μM for IL-1β inhibition. It demonstrates robust metabolic stability in liver microsomes (t1/2 = 138.63 min) and exhibits minimal toxicity (against L02: IC50 > 100 μM) [1].
Smiles
C(=C/N(=O)=O)\C1=C(/C=C/C2=CC=C(NC(=O)C3=CC=CO3)C=C2)C=C(OC)C=C1OC
Molecular Formula
C23H20N2O6
Molecular Weight
420.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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