NLRP3 modulator 8

• Description:

  NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9 nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].

• UNSPSC:

  12352005

• Target:

  Caspase; Interleukin Related; NEKs; NOD-like Receptor (NLR)

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Smiles:

  O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O

• Molecular Formula:

  C20H19Cl2FN4O3

• Molecular Weight:

  453.29

• References & Citations:

  [1]Liardo E, et al. Substituted piperidinediones for targeted protein degradation. WO2025024521A1. 2025-01-30.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 1; IL-1; NEK7

• CAS Number:

  3069891-88-6