NLRP3 modulator 8

• Description :

  NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9 nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-1β release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].

• UNSPSC :

  12352005

• Target :

  Caspase; Interleukin Related; NEKs; NOD-like Receptor (NLR)

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Smiles :

  O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O

• Molecular Formula :

  C20H19Cl2FN4O3

• Molecular Weight :

  453.29

• References & Citations :

  [1]Liardo E, et al. Substituted piperidinediones for targeted protein degradation. WO2025024521A1. 2025-01-30.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 1; IL-1; NEK7

• CAS Number :

  [3069891-88-6]