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EGFR-IN-101

CAT: 0931-T86355-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T86355-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2982583-44-6
Target
EGFR
Related Pathways
JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis
Bioactivity
EGFR-IN-101 (I-10), a 2-phenylamino pyrimidine derivative, is an EGFR inhibitor with IC50 values of 33.26 nM for EGFR L858R/T790M/C797S and 106.4 nM for Ba/F3-EGFR L858R/T790M/C797S. It is applicable in the study of non-small cell lung cancer (NSCLC) [1].
Smiles
C(N[C@H](CO)C)C=1C(=NN(C1)C2=NC(NC3=C(OC)C=C(C(C)=C3)N4CCC(CC4)N5CCN(C)CC5)=NC=C2)C6=CC=CC=C6
Molecular Formula
C35H47N9O2
Molecular Weight
625.81
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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