EGFR-IN-101

• Target:

  EGFR

• Related Pathways:

  JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity:

  EGFR-IN-101 (I-10), a 2-phenylamino pyrimidine derivative, is an EGFR inhibitor with IC50 values of 33.26 nM for EGFR L858R/T790M/C797S and 106.4 nM for Ba/F3-EGFR L858R/T790M/C797S. It is applicable in the study of non-small cell lung cancer (NSCLC) [1].

• Smiles:

  C(N[C@H](CO)C)C=1C(=NN(C1)C2=NC(NC3=C(OC)C=C(C(C)=C3)N4CCC(CC4)N5CCN(C)CC5)=NC=C2)C6=CC=CC=C6

• Molecular Formula:

  C35H47N9O2

• Molecular Weight:

  625.81

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2982583-44-6