BMP-22

• CAS Number :

  1306684-90-1

• Target :

  Others|||PDE

• Related Pathways :

  Metabolism|||Others

• Bioactivity :

  BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM) . It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 ?M. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.

• Smiles :

  C(CCCCCCCCCCCCCC)C1=CC=C(CP(=O)(O)O)C=C1

• Molecular Formula :

  C22H39O3P

• Molecular Weight :

  382.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C