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TPP-IOA

CAT: 0931-T212163-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T212163-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1423018-61-4
Target
Apoptosis, OXPHOS, Mitochondrial Metabolism
Related Pathways
Metabolism, Apoptosis
Bioactivity
TPP-IOA is a cytochrome c peroxidase inhibitor. It prevents apoptosis by blocking cardiolipin oxidation and the release of cytochrome c into the cytosol. TPP-IOA interferes with oxidative phosphorylation in isolated mitochondria. It inhibits cell death of SH-SY5Y cells in glucose medium but is ineffective in galactose medium. Additionally, TPP-IOA induces mitochondrial depolarization and network fragmentation, and it reduces radiation-induced mortality in mice.
Smiles
[P+](CCCOC(CCCCCCC/C=C\C[C@H](CCCCCC)N1C=CN=C1)=O)(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]
Molecular Formula
C42H56BrN2O2P
Molecular Weight
731.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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