TPP-IOA

• Target :

  Apoptosis|||OXPHOS|||Mitochondrial Metabolism

• Related Pathways :

  Metabolism|||Apoptosis

• Bioactivity :

  TPP-IOA is a cytochrome c peroxidase inhibitor. It prevents apoptosis by blocking cardiolipin oxidation and the release of cytochrome c into the cytosol. TPP-IOA interferes with oxidative phosphorylation in isolated mitochondria. It inhibits cell death of SH-SY5Y cells in glucose medium but is ineffective in galactose medium. Additionally, TPP-IOA induces mitochondrial depolarization and network fragmentation, and it reduces radiation-induced mortality in mice.

• Smiles :

  [P+](CCCOC(CCCCCCC/C=C\C[C@H](CCCCCC)N1C=CN=C1)=O)(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]

• Molecular Formula :

  C42H56BrN2O2P

• Molecular Weight :

  731.78

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1423018-61-4