TPP-1

• Target:

  PD-1/PD-L1

• Related Pathways:

  Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation

• Bioactivity:

  TPP-1, a potent inhibitor of the PD-1/PD-L1 interaction, exhibits high affinity for PD-L1, with a dissociation constant (K D) of 95 nM. It effectively inhibits human tumor growth in vivo by reactivating T-cell function [1].

• Smiles:

  C([C@@H](C(N[C@H](C(N[C@H](C(=O)N1[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CO)=O)=O)=O)CO)=O)CCCNC(=N)N)=O)=O)CCC1)CC(O)=O)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@H](CC=2C=3C(NC2)=CC=CC3)NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@H](CC5=CC=C(O)C=C5)NC([C@@H](NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC([C@@H](NC(CNC([C@H](CO)N)=O)=O)CCC(N)=O)=O)=O)C)=O)CO)=O)=O)=O)CS)=O)=O)CS)=O)C=7C=8C(NC7)=CC=CC8

• Molecular Formula:

  C107H150N34O32S2

• Molecular Weight:

  2488.67

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2426685-25-6