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TPP-1

CAT: 0931-T76197-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T76197-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2426685-25-6
Target
PD-1/PD-L1
Related Pathways
Cell Cycle/Checkpoint|||Apoptosis|||Immunology/Inflammation
Bioactivity
TPP-1, a potent inhibitor of the PD-1/PD-L1 interaction, exhibits high affinity for PD-L1, with a dissociation constant (K D) of 95 nM. It effectively inhibits human tumor growth in vivo by reactivating T-cell function [1].
Smiles
C([C@@H](C(N[C@H](C(N[C@H](C(=O)N1[C@H](C(NCC(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CO)=O)=O)=O)CO)=O)CCCNC(=N)N)=O)=O)CCC1)CC(O)=O)=O)CCCNC(=N)N)=O)NC([C@@H](NC([C@H](CC=2C=3C(NC2)=CC=CC3)NC([C@@H](NC([C@H](CC4=CN=CN4)NC([C@H](CC5=CC=C(O)C=C5)NC([C@@H](NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC([C@@H](NC(CNC([C@H](CO)N)=O)=O)CCC(N)=O)=O)=O)C)=O)CO)=O)=O)=O)CS)=O)=O)CS)=O)C=7C=8C(NC7)=CC=CC8
Molecular Formula
C107H150N34O32S2
Molecular Weight
2488.67
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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