ROR1-IN-4

CAT: 0931-MF-0119105-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0119105-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Bcl-2 Family|||PARP|||Apoptosis|||ROR
Related Pathways
Metabolism|||DNA Damage/DNA Repair|||Apoptosis|||Chromatin/Epigenetic
Bioactivity
ROR1-IN-4 is a selective inhibitor of ROR1 with a dissociation constant (Kd) of 52 nM. It exhibits potent antiproliferative activity in the triple-negative breast cancer (TNBC) cell line MDA-MB-231, with an IC50 of 75 nM. ROR1-IN-4 reduces colony formation, induces apoptosis (apoptosis), and inhibits phosphorylation of ROR1 (Tyr786) in these cells. Additionally, ROR1-IN-4 demonstrates significant antitumor efficacy in nude mice bearing subcutaneous MDA-MB-231 xenograft tumors. This compound is applicable for research related to TNBC.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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