ROR1-IN-2

• Description :

  ROR1-IN-2 (compound 9I) is a potent and selective ROR1 inhibitor. ROR1-IN-2 exhibits antiproliferative activity in multiple cancer cells. ROR1-IN-2 significantly suppresses tumor growth in vivo[1].

• UNSPSC :

  12352005

• Target :

  ROR

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  CC(NC1=CC=C(C=C1)C2=CC=CC(NC3=C(C=CC(C(NC4=CC5=C(OCCO5)C=C4)=O)=C3)C)=C2)=O

• Molecular Formula :

  C30H27N3O4

• Molecular Weight :

  493.55

• References & Citations :

  [1]Zheng, Q., et al. Structure-directing optimization of N- (2, 3-dihydrobenzo [b][1, 4] dioxin-6-yl) benzamide derivatives as selective receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitors for cancer therapy. European Journal of Medicinal Chemistry, 117755.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported