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ROR1-IN-4

CAT: 0804-HY-175497Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175497Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ROR1-IN-4 is a selective ROR1 inhibitor with a Kd of 52 nM. ROR1-IN-4 shows potent anti-proliferative activity against TNBC cell line MDA-MB-231 (IC50 = 75 nM) . ROR1-IN-4 reduces colony formation, induces apoptosis and inhibits the phosphorylation of ROR1 (Tyr786) in MDA-MB-231 cells. ROR1-IN-4 demonstrates superior anti-tumor efficacy in nude mice bearing MDA-MB-231 subcutaneous xenografts. ROR1-IN-4 can be used for the study of triple-negative breast cancer (TNBC) [1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; PARP; ROR
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC(C1=CC(NC(C2=CC=C(C(C3=CC=C4N=C(N=CC4=C3)N)=C2)C)=O)=CC=C1CN5CCN(CC5)C)F
Molecular Formula
C29H30F2N6O
Molecular Weight
516.58
References & Citations
[1]Lu D, et al. Structure-Based Discovery of Quinazolin-2-amine Derivatives as Potent ROR1 Pseudokinase Inhibitors with In Vitro and In Vivo Efficacy against Triple-Negative Breast Cancer. J Med Chem. 2025 Aug 14;68 (15) :16138-16171.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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