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ROR1-IN-1

CAT: 0931-T210170-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210170-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3053223-31-4
Target
ROR
Related Pathways
Metabolism
Bioactivity
ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.
Smiles
O=C(NC=1C=CC=2C(=CN(C2C1)C)C=3C=CC(OCOC)=CC3)C4=CC=C(C(C#CC5=CC=NC=6NN=CC56)=C4)C
Molecular Formula
C33H27N5O3
Molecular Weight
541.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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