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PROTAC ROR1 degrader-1

CAT: 0931-T205060-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205060-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, Apoptosis, ROR
Related Pathways
Apoptosis, Metabolism, PROTAC
Bioactivity
PROTACROR1degrader-1 (Compound 11d) serves as a PROTAC degrader targeting the pseudokinase ROR1, with the capability of degrading ROR1 in NSCLC cells at a DC50 of 40-80 nM. It induces PARP cleavage and apoptosis in NCI-H23 cells. [Pink: ligand for target protein ROR1 ligand-1; Black: linker; Blue: ligand for VHL E3 ligase (S, R, S) -AHPC]
Molecular Formula
C55H74BrN11O5S
Molecular Weight
1081.22
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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