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PDIC-NN dimethanesulfonate

CAT: 0931-T211586-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211586-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3040919-39-6
Target
STING, ROS, Apoptosis
Related Pathways
Apoptosis, Immunology/Inflammation
Bioactivity
PDIC-NN dimethanesulfonate (PDIC-NS) is a STING activator with anticancer properties. It increases the levels and stability of endogenous cyclic dinucleotides (CDN) . PDIC-NN dimethanesulfonate triggers a burst of reactive oxygen species (ROS) and causes significant mitochondrial damage. It induces apoptosis and inhibits DNA replication. Additionally, it activates the cGAS-STING signaling pathway, enhancing the immunogenicity of tumor cells and triggering a strong innate immune response.
Smiles
O=C1C2=CC(Cl)=C3C4=C(Cl)C=C5C(=O)N(C(=O)C6=CC(Cl)=C(C=7C(Cl)=CC(C(=O)N1CCN(C)C)=C2C37)C4=C56)CCN(C)C.O=S(=O)(O)C
Molecular Formula
C33H28Cl4N4O7S
Molecular Weight
766.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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