KI-DX-014

CAT: 0931-MF-0118634-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118634-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1309288-83-2
Target
DNA/RNA Synthesis|||ATPase
Related Pathways
Cell Cycle/Checkpoint|||DNA Damage/DNA Repair|||Membrane transporter/Ion channel
Bioactivity
KI-DX-014 is a DDX21 inhibitor with an IC50 of 3.31 ?M. It effectively disrupts the interaction between DDX21 and RNA, modulates ATPase activity, and influences the formation of biomolecular condensates. This compound reduces the release of DDX21-dependent P-TEFb from the 7SK snRNP complex, inhibits RNA polymerase II CTD phosphorylation, and induces developmental defects in zebrafish embryos. KI-DX-014 is applicable in research related to cancer and neurodegenerative diseases.
Smiles
O=C(O)C1(N)CN(CC=2C=NN(C3=CC=C(OC)C=C3)C2C)CC1
Molecular Formula
C17H22N4O3
Molecular Weight
330.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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