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KI-TOX-A3

CAT: 0931-T210914-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210914-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1351116-34-1
Target
Histone Acetyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 μM for the TOX-KAT7 interaction. It promotes proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses CD8+ T cell exhaustion, and inhibits proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 holds potential for research in hematological malignancies, including T-ALL.
Smiles
N#CC1=C(N=C2C=3C=CC(O)=CC3CC2=C1C=4OC(=CC4)CO)N
Molecular Formula
C18H13N3O3
Molecular Weight
319.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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