Mtb-IN-10

• Target:

  Antibacterial|||Antibiotic

• Related Pathways:

  Microbiology/Virology

• Bioactivity:

  Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.

• Molecular Formula:

  C12H14N2O4S2

• Molecular Weight:

  314.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C