ZnPc-O3-JQ1

CAT: 0931-T211273-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211273-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

ROS, HIF/HIF Prolyl-Hydroxylase, Epigenetic Reader Domain

Related Pathways

Metabolism, Immunology/Inflammation, Chromatin/Epigenetic

Bioactivity

ZnPc-O3-JQ1 is a light-activated BRD4 degrader. Under light exposure, ZnPc-O3-JQ1 generates reactive oxygen species (ROS), leading to the degradation of BRD4. This degradation results in the downregulation of HIF-1α, effectively countering the tumor hypoxia-induced resistance to photodynamic therapy (PDT) . ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 includes three components: a BRD4 ligand, a linker, and a photosensitizer.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-176724	ZnPc-O3-JQ1
A8181-100	(-)-JQ1
HY-137075-01	(±) -JQ1
S7110-25mg	(+) -JQ1
sc-472932	(+/-) -JQ1
bs-82200C-01	JQ1 (+/-)
4499/10	(+)-JQ1
bs-82331C-01	JQ1 (+)
TAC52471-01	(-) -JQ1
MBS3601126-01	JQ1

ZnPc-O3-JQ1

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