JQ1 (+/-)

CAT: 0498-bs-82200C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82200C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N) ), BRD4 (C-terminal (C) ), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
RT

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