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ZnPc-O3-JQ1

CAT: 0804-HY-176724Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176724Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZnPc-O3-JQ1 is a light-triggered BRD4 degrader. Under illumination, ZnPc-O3-JQ1 generates reactive oxygen species (ROS) that degrades BRD4. The degradation of BRD4 results in downregulation of HIF-1α, thereby counteracting the photodynamic therapy (PDT) resistance induced by tumor hypoxia. ZnPc-O3-JQ1 exhibits both Type I and Type II PDT mechanisms. The structure of ZnPc-O3-JQ1 consists of three parts: BRD4 ligand ; Linker (HY-W040165) ; Photosensitizer (HY-176725).
UNSPSC
12352211
Target
Epigenetic Reader Domain; HIF/HIF Prolyl-Hydroxylase; Reactive Oxygen Species (ROS)
Related Pathways
Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C=C1)OC2=CC3=C(C4=NC5=[N-]6C(C7=C5C=CC=C7)=NC8=C9C=CC=CC9=C%10N=C%11C%12=C(C%13=[N-]%11[Zn+2](N8%10)6N4C3=N%13)C=CC=C%12)C=C2)CCOCCOCCOCCNC(C[C@@H]%14N=C(C%15=CC=C(Cl)C=C%15)C(C(C)=C(C)S%16)=C%16N%17C%14=NN=C%17C)=O
Molecular Formula
C66H53ClN14O6SZn
Molecular Weight
1271.12
References & Citations
[1]Wang K, et al. Photo-Activated PROTACs for Targeted BRD4 Degradation and Synergistic Photodynamic Therapy in Bladder Cancer. Mol Pharm. 2025 Jun 2;22 (6) :3388-3400.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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