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TAU-IN-3

CAT: 0931-T211092-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211092-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3063511-09-8
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Bioactivity
TAU-IN-3 (Compound 2) is an orally active TAU inhibitor that suppresses the expression of the MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 μM) . It reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein. It modulates tau splicing in htau mice and improves associated behavioral phenotypes. TAU-IN-3 is useful for researching neurodegenerative diseases.
Smiles
O=C1C2=C(N=CN1CCCN(C)CCCC3=CN=C(N)C=C3OC)C=4C=CC=CC4N2C
Molecular Formula
C24H30N6O2
Molecular Weight
434.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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