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TAU-IN-3

CAT: 0804-HY-174215Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174215Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAU-IN-3 (Compound 2) is an orally active TAU inhibitor. TAU-IN-3 inhibits the expression of MAPT exon 10 DDPAC mutant gene in HeLa cells (IC50: 0.6 µM) . TAU-IN-3 reduces the 4R/3R MAPT mRNA ratio in HeLa cells transfected with WT or DDPAC minigenes. TAU-IN-3 inhibits the insertion of endogenous MAPT exon 10 and the production of 4R tau protein in cells. TAU-IN-3 modulates tau splicing in htau mice and improves the associated behavioral phenotypes. TAU-IN-3 can be used to study neurodegenerative diseases[1].
CAS Number
3063511-09-8
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CN(C1=C2N=CN(CCCN(C)CCCC3=CN=C(N)C=C3OC)C1=O)C4=C2C=CC=C4
Molecular Formula
C24H30N6O2
Molecular Weight
434.53
References & Citations
[1]Zhang P, et al. Design of an Orally Bioavailable Small Molecule That Modulates the Microtubule-Associated Protein Tau's Pre-mRNA Splicing. ACS Chem Biol. 2025 Jun 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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