CDK-IN-18

• Target:

  CDK

• Related Pathways:

  Cell Cycle/Checkpoint

• Bioactivity:

  CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant, and selective inhibitor of CDK2, CDK4, and CDK6. It hinders the activity of cyclin-CDK complexes, preventing the phosphorylation of retinoblastoma protein (pRb), and thereby blocks the transition of cells from the G1 phase to the S phase. CDK-IN-18 shows potential for cancer research, such as in breast cancer (particularly hormone receptor-positive, HER2-negative types), lung cancer, and colorectal cancer.

• Smiles:

  C(C)(C)C1=C2N(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5C(=O)C[C@@H](N(C)C)CC5)=NC=C3)N=C1

• Molecular Formula:

  C26H30N8O

• Molecular Weight:

  470.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2531743-46-9