CDK-IN-18

CAT: 0931-T211060-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T211060-01Size:10 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
2531743-46-9
Target
CDK
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
CDK-IN-18 (Compound EX.161) is an orally active, brain-penetrant, and selective inhibitor of CDK2, CDK4, and CDK6. It hinders the activity of cyclin-CDK complexes, preventing the phosphorylation of retinoblastoma protein (pRb), and thereby blocks the transition of cells from the G1 phase to the S phase. CDK-IN-18 shows potential for cancer research, such as in breast cancer (particularly hormone receptor-positive, HER2-negative types), lung cancer, and colorectal cancer.
Smiles
C(C)(C)C1=C2N(C=CC(=C2)C3=NC(NC4=CC=C(C=N4)N5C(=O)C[C@@H](N(C)C)CC5)=NC=C3)N=C1
Molecular Formula
C26H30N8O
Molecular Weight
470.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T75127-01CDK-IN-12
T201193-01CDK-IN-15
T36741-01CDK-IN-6
T62235-01CDK-IN-9
T60869-01CDK-IN-10
T208739-01CDK-IN-13
T84917-01CDK-IN-11
TQ0078-01CDK-IN-2
T201211-01CDK-TCIP2
T204162-01CDK-IN-16

Alternative Products

CatalogName
HY-201330CDK-IN-18
M35483-01CDK-IN-10
MBS5797812-01CDK-IN-6
MBS5817050CDK-IN-12
HY-13033-01CDK-IN-2
MBS5804923CDK-IN-9
HY-170507CDK-IN-16
HY-168067CDK-IN-14
HY-149173-01CDK-IN-11
HY-157297CDK-IN-13

Popular Products