Bcl-2-IN-7

• Target :

  Caspase|||Apoptosis|||Bcl-2 Family|||MDM-2/p53|||Others

• Related Pathways :

  Others|||Proteases/Proteasome|||Apoptosis

• Bioactivity :

  Bcl-2-IN-7 is a potent inhibitor of Bcl-2 (b-cell lymphoma-2), which can downregulate the expression of Bcl-2, increase the expression of p53, Bax, caspase-7 mRNA, and induce cell cycle arrest and apoptosis in MCF-7 cells of breast cancer. Bcl2-IN-7 showed good antitumor activity against MCF-7 cells (IC50: 20.17 ?M), LoVo cells (IC50: 22.64 ?M), HepG2 cells (IC50: 45.57 ?M) and A549 cells (IC50: 51.50 ?M) .

• Molecular Formula :

  C24H22N4O5S2

• Molecular Weight :

  510.59

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C