USP1-IN-11

CAT: 0931-T205601-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T205601-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

DUB

Related Pathways

Ubiquitination, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Bioactivity

USP1-IN-11 (compound 38-P2) is a selective, reversible, and non-competitive inhibitor of USP1 (Ubiquitin-specific protease 1) . It promotes the activation of the DDR (DNA damage repair) pathway, inducing cell cycle arrest and apoptosis, thereby inhibiting cell viability. USP1-IN-11 increases the sensitivity of cells resistant to Olaparib and shows synergistic effects with Andrographolide in cancer cells with normal BRCA function. In the MDA-MB-436 xenograft model, USP1-IN-11 exhibits a significant dose-dependent antitumor effect.

Molecular Formula

C31H30F3N7O3

Molecular Weight

605.61

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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