Products for Research Use Only
RegisterLogin

STAT3-IN-27

CAT: 0931-T209873-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T209873-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
STAT, Apoptosis
Related Pathways
JAK/STAT signaling, Apoptosis, Stem Cells
Bioactivity
STAT3-IN-27 (Compound 41) is an orally active STAT3 inhibitor that impedes STAT3 phosphorylation with a KD of 4.4 μM and suppresses STAT3 transcriptional activity with an IC50 of 22.57 nM. It inhibits the proliferation of various cancer cells with an IC50 ranging from 10 to 500 nM. STAT3-IN-27 causes cell cycle arrest at the G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116 cells, and inhibits HCT116 cell migration. It exhibits antitumor effects in mouse models.
Molecular Formula
C18H21N3O4S
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T211942-01STAT3-IN-43
T211656-01STAT3-IN-44
T203638-01STAT3-IN-37
T200371-01STAT3-IN-34
TP2627-01STAT3-IN-23
T28865-01STAT3-IN-B9
T62803-01STAT3-IN-12
T71550-01STAT3-IN-8
T71351-01STAT3-IN-A69
T203450-01STAT3-IN-38

Alternative Products

CatalogName
HY-161644STAT3-IN-27
335744-01Stat3

Popular Products