AurkA allosteric-IN-1

CAT: 0931-T209475-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T209475-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Aurora Kinase

Related Pathways

Cell Cycle/Checkpoint, Chromatin/Epigenetic

Bioactivity

AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor with an IC50 of 6.50 μM, which inhibits both the catalytic and non-catalytic activities of Aurora A. Aurora A is involved in the regulation of bipolar mitotic spindle assembly and the fidelity of chromosome segregation during mitosis. AurkA allosteric-IN-1 interferes with Aurora A by binding to the Y-pocket, thereby preventing its interaction with the activator TPX2.

Molecular Formula

C20H16N2O3

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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AurkA allosteric-IN-1

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