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AURKA-IN-1

CAT: 0804-HY-161407Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161407Size:1 Each
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Description
AURKA-IN-1 (compound 9) is an cell-active covalent AURKA inhibitor. AURKA-IN-1 is a lysine-reactive activity probe[1].
UNSPSC
12352005
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/aurka-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC#C)C1=CC(NC2=NNC(C3CC3)=C2)=NC(N4CCN(C(C5=CC=C(OS(=O)(F)=O)C=C5)=O)CC4)=N1
Molecular Formula
C25H25FN8O5S
Molecular Weight
568.58
References & Citations
[1]Guanghui Tang, et al. Global Reactivity Profiling of the Catalytic Lysine in Human Kinome for Covalent Inhibitor Development. Angew Chem Int Ed Engl. 2024, 63, 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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