Thalidomide-O-C5-azide

• Target :

  E3 Ligase Ligand-Linker Conjugate

• Related Pathways :

  PROTAC

• Bioactivity :

  Thalidomide-O-C5-azide is a modified form of the cereblon (CRBN) inhibitor thalidomide, created through click chemistry. It contains an azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkynyl-containing molecules. Thalidomide-O-C5-azide serves as a ligand and linker conjugate for E3 ubiquitin ligase, facilitating the synthesis of PROTACs.

• Smiles :

  [N-]=[N+]=NCCCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

• Molecular Formula :

  C18H19N5O5

• Molecular Weight :

  385.37

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2411098-96-7