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Thalidomide-O-C3-azide

CAT: 0931-T208674-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T208674-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2758432-00-5
Target
E3 Ligase Ligand-Linker Conjugate
Related Pathways
PROTAC
Bioactivity
Thalidomide-O-C3-azide is a chemically modified version of the cereblon (CRBN) inhibitor Thalidomide through click chemistry. It features an azido group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Thalidomide-O-C3-azide serves as a ligand for E3 ubiquitin ligase and a component in E3 Ligase Ligand-Linker Conjugates, facilitating the synthesis of PROTACs.
Smiles
[N-]=[N+]=NCCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3
Molecular Formula
C16H15N5O5
Molecular Weight
357.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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