Thalidomide 4'-ether-PEG2-azide

• Target:

  E3 Ligase Ligand-Linker Conjugate

• Related Pathways:

  PROTAC

• Bioactivity:

  Thalidomide 4'-ether-PEG2-azide is a modified form of the cereblon (CRBN) inhibitor Thalidomide, created through click chemistry. Featuring an azide group, this compound can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It serves as a ligand for E3 ubiquitin ligase and as a linker conjugate (E3LigaseLigand-Linker Conjugates) for use in PROTACs.

• Smiles:

  [N-]=[N+]=NCCOCCOCCOC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3

• Molecular Formula:

  C19H21N5O7

• Molecular Weight:

  431.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2758431-90-0