Thalidomide 4'-ether-PEG2-azide

• Target :

  E3 Ligase Ligand-Linker Conjugate

• Related Pathways :

  PROTAC

• Bioactivity :

  Thalidomide 4'-ether-PEG2-azide is a modified form of the cereblon (CRBN) inhibitor Thalidomide, created through click chemistry. Featuring an azide group, this compound can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. It serves as a ligand for E3 ubiquitin ligase and as a linker conjugate (E3LigaseLigand-Linker Conjugates) for use in PROTACs.

• Smiles :

  [N-]=[N+]=NCCOCCOCCOC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

• Molecular Formula :

  C19H21N5O7

• Molecular Weight :

  431.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2758431-90-0