Thalidomide 4'-ether-PEG1-azide

• Description:

  Thalidomide 4'-ether-PEG1-azide is the Thalidomide (HY-14658) -based cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4'-ether-PEG1-azide can be connected to the ligand for protein by a linker to form PROTACs[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-4-ether-peg1-azide.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [N-]=[N+]=NCCOCCOC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O

• Molecular Formula:

  C17H17N5O6

• Molecular Weight:

  387.35

• References & Citations:

  [1]Chen P, et al. α-naphthoflavone-derived cytochrome P450 (CYP) 1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship. Bioorg Chem. 2021 Nov;116:105295.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cereblon

• CAS Number:

  [2758432-02-7]