JTT-553

• Target :

  Acyltransferase

• Related Pathways :

  Metabolism

• Bioactivity :

  JTT-553 is a DGAT1 inhibitor with an IC50 of 2.38 nM. It effectively reduces plasma levels of glucose, insulin, non-esterified fatty acids (NEFA), total cholesterol (TC), and liver triglycerides (TG) . JTT-553 enhances insulin-dependent glucose absorption and glucose intolerance in the adipose tissue of diet-induced obese (DIO) mice. In KK-Ay mice, it lowers TNF-? mRNA levels and elevates GLUT4 mRNA levels in adipose tissue. By contributing to weight loss, JTT-553 improves insulin resistance in adipose tissue and overall glucose metabolism. This compound is useful for research on obesity and type 2 diabetes mellitus (T2DM) .

• Smiles :

  C(C(O)=O)[C@H]1CC[C@]2(C=3C(CC2)=CC(=CC3)C4=NC=5C(OC4(C)C)=NC(C(F)(F)F)=NC5N)CC1

• Molecular Formula :

  C25H27F3N4O3

• Molecular Weight :

  488.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  701232-94-2