JTT-654

• Target:

  Dehydrogenase

• Related Pathways:

  Metabolism

• Bioactivity:

  JTT-654 is a potent and selective orally active inhibitor of 11?-Hydroxysteroid dehydrogenase type 1 (11?-HSD1) . It exhibits IC50 values of 4.65, 0.97, and 0.74 nM for human, rat, and mouse recombinant enzymes, respectively, and demonstrates competitive inhibition against the human recombinant enzyme. The IC50 value for human 11?-HSD2 is greater than 30 ?M, as this enzyme is responsible for the reverse reaction against human 11?-HSD1. JTT-654 improves insulin resistance and non-obese type 2 diabetes by targeting 11?-HSD1 in adipose tissue and the liver [1] [2].

• Smiles:

  C(=O)(C1=C(N(N=C1)C2CCN(C(=O)C3(CO)CC3)CC2)C4CC4)N5C[C@@H](CC5)C6=C(C(F)(F)F)C=CC=C6

• Molecular Formula:

  C28H33F3N4O3

• Molecular Weight:

  530.58

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  916828-66-5