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JTT-654

CAT: 0931-T86776-01Size: 10 mgDry Ice: NoHazardous: No
CAT#: T86776-01Size: 10 mg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
916828-66-5
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
JTT-654 is a potent and selective orally active inhibitor of 11?-Hydroxysteroid dehydrogenase type 1 (11?-HSD1) . It exhibits IC50 values of 4.65, 0.97, and 0.74 nM for human, rat, and mouse recombinant enzymes, respectively, and demonstrates competitive inhibition against the human recombinant enzyme. The IC50 value for human 11?-HSD2 is greater than 30 ?M, as this enzyme is responsible for the reverse reaction against human 11?-HSD1. JTT-654 improves insulin resistance and non-obese type 2 diabetes by targeting 11?-HSD1 in adipose tissue and the liver [1] [2].
Smiles
C(=O)(C1=C(N(N=C1)C2CCN(C(=O)C3(CO)CC3)CC2)C4CC4)N5C[C@@H](CC5)C6=C(C(F)(F)F)C=CC=C6
Molecular Formula
C28H33F3N4O3
Molecular Weight
530.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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