TAK-075

• Target:

  CaSR

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.

• Smiles:

  S(=O)(=O)(O)C1=CC=C(C)C=C1.C(NC(CC)(CC)C1=CC=C(CC)C=C1)(=O)C2=C3N(C(C)(C)C[C@@H](N3)C4=CC=CC=C4)N=C2C

• Molecular Formula:

  C36H46N4O4S

• Molecular Weight:

  630.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  667931-33-1