Products for Research Use Only

PDHK1-IN-2

CAT: 0931-T206446-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206446-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2870691-38-4
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinase 1/2 (PDHK1/2), with an IC50 of 0.007 μM for PDHK1 and 0.015 μM for PDHK2. PDHK1-IN-2 has the potential to regulate immune cell metabolism and correct mitochondrial dysfunction, making it a promising candidate for research in autoimmune diseases, inflammatory conditions, and cancer.
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C(C)C1(C=2C(NC1=O)=C(NCC)C=C(F)C2)N3C[C@H](NC(=O)C4CC5(C4)CN(C#N)C5)CCC3
Molecular Formula
C25H33FN6O2
Molecular Weight
468.567
Shipping Conditions
Ice Packs
Storage Temperature
-20°C