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PDHK1-IN-2

CAT: 0804-HY-173298Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173298Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDHK1-IN-2 (Compound 24) is an ATP-competitive dual inhibitor of pyruvate dehydrogenase kinases 1/2 (PDHK1/2), with an IC50 of 0.007 μM for PDHK1 and an IC50 of 0.015 μM for PDHK2. PDHK1-IN-2 can regulate immune cell metabolism and correct mitochondrial dysfunction, and is expected to be used in the research of autoimmune diseases, inflammatory diseases, cancers, and other conditions[1].
CAS Number
2870691-38-4
UNSPSC
12352005
Target
PDHK
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
CCNC1=CC(F)=CC(C2(CC)N3CCC[C@@H](NC(C4CC5(CN(C#N)C5)C4)=O)C3)=C1NC2=O
Molecular Formula
C25H33FN6O2
Molecular Weight
468.57
References & Citations
[1]Xu H, et al. Discovery of ATP competitive PDHK1/2 dual inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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