EIF4E-IN-4

• Target:

  PERK

• Related Pathways:

  Apoptosis

• Bioactivity:

  EIF4E-IN-4 (Compound 33) is a selective inhibitor of the eukaryotic initiation factor 4E (eIF4E) with a biochemical activity value of 95 nM. It inhibits cap-dependent mRNA translation with an IC50 of 2.5 ?M and is applicable in research on breast cancer, colon cancer, and head and neck cancer.

• Smiles:

  O=C1N=C(NC=2N=C(C=3C=CC(=CC3)P(=O)(O)O)N(C12)CCOC4=CC=C(Cl)C=C4)NC

• Molecular Formula:

  C20H19ClN5O5P

• Molecular Weight:

  475.822

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1373822-39-9