Cath-L-dBET1

• Target:

  Epigenetic Reader Domain|||PROTACs

• Related Pathways:

  Chromatin/Epigenetic|||PROTAC

• Bioactivity:

  Cath-L-dBET1 is a PROTAC degrader targeting BRD4. It has an IC50 value of 2.8 ?M in MDA-MB-231 cells. Activated by cathepsin L (Cath-L), Cath-L-dBET1 recruits E3 ubiquitin ligase to degrade BRD4 via the ubiquitin-proteasome system. Hyp-dBET1 is applicable for antitumor research.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C