DBET1

• Target:

  Epigenetic Reader Domain|||PROTACs

• Related Pathways:

  PROTAC|||Chromatin/Epigenetic

• Purity:

  0.993

• Bioactivity:

  DBET1 is a hybrid molecule that combines (+) -JQ1 and thalidomide. It induces cereblon-dependent BET protein degradation in vitro (EC50: 430 nM) and induces apoptosis.

• Smiles:

  CC=1C2=C(N3C([C@H](CC(NCCCCNC(COC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C

• Molecular Formula:

  C38H37ClN8O7S

• Molecular Weight:

  785.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1799711-21-9