DS-1558

• Target:

  Others|||GRK

• Related Pathways:

  Others|||GPCR/G Protein

• Bioactivity:

  DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.

• Smiles:

  C(F)(F)(F)C1=C2C([C@H](OC3=CC=C([C@H](CC(O)=O)OCC)C=C3)CC2)=CC=C1

• Molecular Formula:

  C21H21F3O4

• Molecular Weight:

  394.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1202575-67-4