DS-1558

CAT: 0931-T71251-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T71251-01Size:25 mg
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CAS Number
1202575-67-4
Target
Others|||GRK
Related Pathways
Others|||GPCR/G Protein
Bioactivity
DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinogenic effects of GLP-1 after an intravenous glucose injection in normal Sprague Dawley rats.
Smiles
C(F)(F)(F)C1=C2C([C@H](OC3=CC=C([C@H](CC(O)=O)OCC)C=C3)CC2)=CC=C1
Molecular Formula
C21H21F3O4
Molecular Weight
394.38
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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