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SMD-1087

CAT: 0931-T205121-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T205121-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3033586-04-5
Target
PROTACs|||Others
Related Pathways
PROTAC|||Others
Bioactivity
SMD-1087 is a selective PROTAC targeting SMARCA2 with a DC50 of 8 nM and a maximum degradation (Dmax) of 89%, while its DC50 for SMARCA4 exceeds 1 ?M. The compound is composed of an E3 ligase ligand, (S, R, S) -AHPC-Me [blue part], a target protein ligand SMI-1074 [red part], and a PROTAC linker, (1r,4r) -tert-Butyl 4- (bromomethyl) cyclohexanecarboxylate [black part]. Notably, its target protein ligand plus linker section corresponds to the SMARCA2 Ligand-Linker Conjugate-1.
Smiles
O=C1N=C2C3(C=4C(N2C=5C1=C(Cl)C=CC5)=CC(=CC4)C6CCN(C[C@H]7CC[C@H](C(N[C@H](C(=O)N8[C@H](C(N[C@@H](C)C9=CC=C(C=C9)C=%10SC=NC%10C)=O)C[C@@H](O)C8)C(C)(C)C)=O)CC7)CC6)CCCCC3
Molecular Formula
C56H68ClN7O5S
Molecular Weight
986.701
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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